Breast Angiosarcoma: Imaging Features With Histopathologic Correlation

Abstract Breast angiosarcoma is a rare malignancy of endothelial origin that can be categorized as primary (PAS) or secondary (SAS) based on etiology. Primary typically affects younger women with no known risk factors, whereas SAS the breast develops in older who have undergone cancer treatment. There are two types SAS, one setting chronic lymphedema and radiation-associated neoplasm after breast-conserving therapy (BCT). Clinically, PAS often presents palpable mass may rapidly growing, skin changes such erythematous plaques nodules areas discoloration. Mammographically, appearance nonspecific obscured by dense tissue characteristic young patient population it affects. Cases mammographically occult been visible at US MRI. Mammography found to less sensitive than MRI for diagnosis angiosarcoma. Angiosarcomas, both graded, depending degree differentiation, low, intermediate, high grade. Endothelial markers ERG CD31 immunohistochemical stains used support angiosarcomas. In this article, we review clinical presentation, imaging findings, associated histopathology, treatment